The Role of Crosstalk between AR3 and E2F1 in Drug Resistance in Prostate Cancer Cells.

Jin XuXi YangDhanraj DeshmukhHegang Chen Shengyun FangYun Qiu

Published in: Cells (2020)

This proof-of-principle study demonstrates that targeting the E2F1/AR3 feedforward loop via a combination therapy or a multi-targeting drug could circumvent castration resistance in prostate cancer.

Keyphrases

combination therapy
prostate cancer
cancer therapy
radical prostatectomy
transcription factor
emergency department
adverse drug