m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency.

Gaocai LiRongjin LuoWeifeng ZhangShujie HeBingjin WangHuaizhen LiangYu SongWencan KeYunsong ShiXiaobo FengKangcheng ZhaoXinghuo WuYukun ZhangKun WangCao Yang

Published in: Clinical and translational medicine (2022)

Collectively, our findings reveal an epigenetic interplay mechanism in NPC senescence and IVD degeneration, presenting a critical pro-senescence role of ALKBH5 and m6A hypomethylation, highlighting the therapeutic potential of targeting the m6A/DNMT3B/E4F1 axis for treating IVD degeneration.

Keyphrases

dna methylation
dna damage
genome wide
endothelial cells
gene expression
stress induced
case report
anti inflammatory
replacement therapy
drug delivery