Prognostic value of histopathological DCIS features in a large-scale international interrater reliability study.
Emma J GroenJan HudecekLennart MulderMaartje van SeijenMathilde M AlmekindersStoyan AlexovAnikó KovácsAles RyskaZsuzsanna VargaFrancisco-Javier Andreu NavarroSimonetta BianchiWillem VreulsEva BalslevMax V BootJanina KulkaEwa ChmielikEllis BarbéMathilda J de RooijWinand VosAndrea FarkasNatalja E Leeuwis-FedorovichPeter RegitnigPieter J WestenendLoes F S KooremanCecily QuinnGiuseppe FlorisGábor CserniPaul J van DiestEsther H LipsMichael SchaapveldJelle Wesselingnull nullPublished in: Breast cancer research and treatment (2020)
Using majority opinion-based scores, DCIS grade, growth pattern, and mitotic activity are associated with iIBC risk in patients treated with BCS-RT, but interrater variability is substantial. Semi-quantitative grading, incorporating and separately evaluating nuclear pleomorphism, growth pattern, and mitotic activity, may improve the reliability and prognostic value of these features.
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