Wnt Signaling Stimulates Cooperation between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma.

Shinji Matsumoto Akikazu Harada Minami Seta Masayuki Akita Hidetoshi Gon Takumi Fukumoto Akira Kikuchi

Published in: Cancer research (2023)

GREB1 is a liver cancer-specific Wnt signaling target gene that induces an oncogenic shift of HNF4α, a putative tumor suppressor, and may represent a therapeutic target in Wnt-activated hepatocellular carcinoma.

Keyphrases

nuclear factor
stem cells
signaling pathway
cell proliferation
genome wide
transcription factor
gene expression
inflammatory response