Anticancer Effects of Antihypertensive L-Type Calcium Channel Blockers on Chemoresistant Lung Cancer Cells via Autophagy and Apoptosis.

Bing-Sang WongLing-Yen ChiuDom-Gene TuGwo-Tarng SheuTing-Tat Chan

Published in: Cancer management and research (2020)

Verapamil combined with DOC or VCR induces chemoresistant lung cancer cells to death through autophagy burst and apoptosis more strongly than Diltiazem and Nifedipine. Administering Verapamil or Diltiazem individually with chemotherapy, but not Nifedipine, can be considered in lung cancer patients with hypertension.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
cell cycle arrest
blood pressure
signaling pathway
high frequency
locally advanced
hypertensive patients
squamous cell carcinoma
radiation therapy
pi k akt
cell proliferation