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Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.

Agnieszka AntosAnna CzłonkowskaLukasz SmolinskiJan BembenekAdam PrzybyłkowskiMarta SkowrońskaIwona Kurkowska-JastrzębskaTomasz Litwin
Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
Given its occurrence in up to 21.8% of patients with neurological WD in this meta-analysis of small studies, there is a need for further investigations to distinguish the natural time course of WD from treatment-related early deterioration and to develop a standard definition for treatment-induced effects.
Keyphrases
  • risk assessment
  • oxidative stress
  • blood brain barrier
  • drug induced