JAK2 deficiency improves erectile function in diabetic mice through attenuation of oxidative stress, apoptosis, and fibrosis.

Hao Li Wenchao XuXiaming LiuTao WangShaogang WangJihong LiuHongyang Jiang

Published in: Andrology (2021)

Our study showed that JAK2 deficiency could improve erectile function in diabetic mice, which might be mediated by reduction in oxidative stress, apoptosis, and fibrosis in corpus cavernosum.

Keyphrases

oxidative stress
diabetic rats
induced apoptosis
dna damage
ischemia reperfusion injury
endoplasmic reticulum stress
cell cycle arrest
cell death
replacement therapy
benign prostatic hyperplasia
heat shock
liver fibrosis