The Potential Transcriptomic and Metabolomic Mechanisms of ATO and ATRA in Treatment of FLT3-ITD Acute Myeloid Leukemia.
Chun-Jin PengZhong FanJie-Si LuoLi-Na WangYu LiCong LiangXiao-Li ZhangXue-Qun LuoLi-Bin HuangYan-Lai TangPublished in: Technology in cancer research & treatment (2024)
The gene transcription profile and metabolites of FLT3-ITD mutant cells changes significantly after treatment, which might be related to the anti-FLT3-ITD AML effect. The screened DEGs, differential metabolites pathway are helpful in studying the mechanism of anti-leukemia effects and drug targets.
Keyphrases
- acute myeloid leukemia
- allogeneic hematopoietic stem cell transplantation
- ms ms
- induced apoptosis
- cell cycle arrest
- genome wide
- single cell
- rna seq
- emergency department
- drug induced
- signaling pathway
- dna methylation
- risk assessment
- cell death
- replacement therapy
- cell proliferation
- adverse drug
- combination therapy
- wild type
- genome wide analysis