Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study.
Jakob SkovDaniel ErikssonRalf Kuja-HalkolaJonas HöijerSoffia GudbjörnsdottirAnn-Marie SvenssonPatrik K E MagnussonJonas F LudvigssonOlle KämpeSophie BensingPublished in: European journal of endocrinology (2020)
Overall, co-aggregation was more pronounced in monozygotic than in dizygotic twins, suggesting that disease overlap is largely attributable to genetic factors. Co-aggregation was common, and twins faced up to a ten-fold risk of developing diseases not present in their co-twin. Our results validate and refine previous heritability estimates based on smaller twin cohorts.