A New, Biomimetic Collagen-Apatite Wound-Healing Composite with a Potential Regenerative and Anti-Hemorrhagic Effect in Dental Surgery.
Barbara KolodziejskaLukasz PajchelAnna ZgadzajJoanna KolmasPublished in: Materials (Basel, Switzerland) (2022)
The aim of this work was to obtain and characterize composite biomaterials containing two components, namely carbonated hydroxyapatite, which was substituted with Mg 2+ and Zn 2+ ions, and natural polymer-collagen protein. The following two different types of collagen were used: lyophilized powder of telocollagen from bovine Achilles tendon and atelocollagen solution from bovine dermis. The obtained 3D materials were used as potential matrices for the targeted delivery of tranexamic acid for potential use in wound healing after tooth extractions. Tranexamic acid (TXA) was introduced into composites by two different methods. The physicochemical analyses of the obtained composites included Fourier-transform infrared spectroscopy (FT-IR), inductively coupled plasma-optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM), scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), release kinetics tests, swelling test, and cytotoxicity assays. The studies showed that the proposed synthetic methods yielded biomaterials with favorable physicochemical properties, as well as the expected release profile of the drug and ions from the matrices.
Keyphrases
- electron microscopy
- wound healing
- tissue engineering
- high resolution
- aqueous solution
- human health
- stem cells
- quantum dots
- mesenchymal stem cells
- minimally invasive
- magnetic resonance
- bone regeneration
- emergency department
- solid state
- computed tomography
- mass spectrometry
- heavy metals
- protein protein
- molecular docking
- gold nanoparticles
- cell therapy
- coronary artery bypass
- percutaneous coronary intervention
- single molecule
- small molecule
- high throughput
- ms ms
- climate change
- single cell
- oral health
- high speed