Interferon-α2 Auto-antibodies in Convalescent Plasma Therapy for COVID-19.

Matthijs P RaadsenArvind GharbharanCarlijn C E JordansAnna Z MykytynMart M LamersPetra B van den DoelHenrik EndemanJohannes P C van den AkkerCorine H GeurtsvanKesselMarion P G KoopmansCasper RokxMarco GoeijenbierEric C M van GorpBart J A RijndersBart L Haagmans

Published in: Journal of clinical immunology (2021)

IFN-α2 Abs were detected by ELISA and neutralization assay in COVID-19 patients, but not in ICU patients with other respiratory illnesses. The presence of neutralizing IFN-α2 Abs in critically ill COVID-19 is associated with delayed viral clearance. IFN-α2 Abs in COVID-19 convalescent plasma donors were not neutralizing in the conditions tested.

Keyphrases

sars cov
coronavirus disease
dendritic cells
immune response
respiratory syndrome coronavirus
intensive care unit
dengue virus
high throughput
mechanical ventilation