Harnessing regulatory T cells to establish immune tolerance.
Patrick HoEllen Cahir-McFarlandJason D FontenotTracey LodieAdel NadaQizhi TangLaurence A TurkaJeffrey A BluestonePublished in: Science translational medicine (2024)
Engineered regulatory T (T reg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T reg cell therapies in treating autoimmune and other inflammatory diseases.
Keyphrases
- regulatory t cells
- induced apoptosis
- dendritic cells
- cell cycle arrest
- single cell
- oxidative stress
- cell therapy
- multiple sclerosis
- small molecule
- transcription factor
- big data
- immune response
- endoplasmic reticulum stress
- cell death
- signaling pathway
- risk assessment
- drug induced
- mesenchymal stem cells
- bone marrow
- pi k akt
- climate change