Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.

Navid J Ayon Cody E EarpRaveena GuptaFatma A ButunAshley E ClementsAlexa G LeeDavid DainkoMatthew T RobeyManead Khin Lina Mardiana Alexandra Longcake Manuel Rangel-Grimaldo Michael John Hall Michael Richard Probert Joanna E Burdette Nancy P Keller Huzefa A Raja Nicholas H Oberliels Michael P Snyder Lindsay K Caesar

Published in: Metabolomics : Official journal of the Metabolomic Society (2024)

This work demonstrates how the incorporation of biochemometrics as a third dimension into the metabologenomics workflow can identify bioactive metabolites and link them to their biosynthetic machinery.

Keyphrases

genome wide
ms ms
copy number
molecular docking
dna methylation
electronic health record
genome wide identification
gene expression
cell wall
molecular dynamics simulations
transcription factor
genome wide analysis
tissue engineering