Banff Human Organ Transplant Transcripts Correlate with Renal Allograft Pathology and Outcome: Importance of Capillaritis and Subpathologic Rejection.
Ivy A RosalesGrace K MahowaldKristen TomaszewskiKiyohiko HottaNaoya IwaharaTakuya OtsukaTakahiro TsujiYusuke TakadaEllen AcheampongMilagros Araujo-MedinaAmy BruceAndrea RiosAnthony Benedict CosimiNahel EliasTatsuo KawaiHannah GilliganKassem SafaLeonardo V RiellaNina E Tolkoff-RubinWinfred W WilliamsRex Neal SmithRobert B ColvinPublished in: Journal of the American Society of Nephrology : JASN (2022)
Peritubular capillary inflammation and DSA are the primary drivers of AMR transcript elevation. Transcripts revealed subpathological evidence of AMR, which often preceded histologic CAMR and subpathological evidence of TCMR that predicted graft loss in CAMR.
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