Letter to the Editor: Relevance of Circulating Extracellular Vesicles Carrying Sphingolipid Cargo in Alcoholic Hepatitis: Need for More Validation!

The study by Sehrawat et al. made an important observation that extracellular vesicles (EVs) and sphingolipid cargoes can distinguish alcoholic hepatitis from decompensated cirrhosis. The authors suggest that an EV value of 1.56 × 1011 /mL will help in differentiating alcoholic hepatitis and also predict 90-day survival, permitting risk profiling and thus having important clinical implications.(1).