Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study.
Martin WallinPatricia TangRachel Yoon Kyung ChangMingshi YangWarren H FinlayHak-Kim ChanPublished in: BMC pulmonary medicine (2019)
In conclusion, delivering a third of inhalable powder to the lungs is possible in vitro through an NHF system using a low dispersion airflow and a highly dispersible powder. Our results may lay the foundation for clinical evaluation of powder aerosol delivery to the lungs during NHF therapy in humans.