OCCUPATIONAL APPLICATIONSMusculoskeletal disorders are prevalent among warehouse workers who engage in repetitive and dynamic tasks. To prevent such injuries, it is vital to identify the factors that influence fatigue in the upper extremities during these repetitive activities. Our study reveals that task factors, namely the bottle mass and picking rate, significantly influence upper extremity fatigue. In most cases, the fatigue indicator is a functional variable, meaning that the fatigue score or measurement is a curve captured over time, which could be modeled as a function. In this study, we demonstrate that functional data analysis tools, such as functional analysis of variance (FANOVA), prove more effective than traditional methods in specifying how task factors contribute to the development of fatigue in the upper extremities. Furthermore, since there are inherent differences among workers that could affect their fatigue development process, the data heterogeneity could be tackled by employing clustering methods.