Effects of the ABCC8 R1420H loss-of-function variant on beta-cell function, diabetes incidence, and retinopathy.

Elsa Vazquez-ArreolaWilliam C KnowlerLeslie J BaierRobert L Hanson

Published in: BMJ open diabetes research & care (2023)

R1420H variant is associated with increased risks of diabetes and of retinopathy, which may be partially explained by higher glycemia levels and worse beta-cell function.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
risk factors
human health
risk assessment
adipose tissue