Porcine circovirus type 2 upregulates endothelial-derived IL-8 production in porcine iliac artery endothelial cells via the RIG-I/MDA-5/MAVS/JNK signaling pathway.

Fengyang ShiQiuming LiShiyu LiuFengying LiuJianfang WangDefeng CuiXiaolin HouShuanghai ZhouYonghong ZhangHuanrong Li

Published in: BMC veterinary research (2020)

PCV2 can activate RIG-I/MDA-5/MAVS/JNK signaling pathway to induce the production of endothelial-derived IL-8 in PIECs, which provides an insight into the further study of endothelial dysfunction and vascular system disorder caused by PCV2.

Keyphrases

signaling pathway
endothelial cells
pi k akt
induced apoptosis
breast cancer cells
epithelial mesenchymal transition
cell cycle arrest
cell death
high glucose
vascular endothelial growth factor
endoplasmic reticulum stress
cell proliferation
endovascular treatment