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CD81 fusion alters SARS-CoV-2 Spike trafficking.

Allaura S ConeYijun ZhouRyan P McNamaraAnthony B EasonGabriel F AriasJustin T LandisKyle W ShifflettMeredith G ChambersRunjie YuanSmaranda WillcoxJack D GriffithDirk P Dittmer
Published in: mBio (2024)
The severe acute respiratory syndrome coronavirus 2 pandemic caused the biggest public health crises in recent history. To understand the maturation pathway of S, we fused S to the tetraspanin protein CD81. The resulting molecule is secreted in extracellular vesicles and induces antibodies in mice. This may be a general design path for viral glycoprotein vaccines.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • public health
  • coronavirus disease
  • nk cells
  • high fat diet induced
  • protein protein
  • amino acid
  • binding protein
  • insulin resistance
  • adipose tissue