TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.

Engin DemirdizenRuslan Al-AliAshwin NarayananXueyuan SunJulianna Patricia VargaBianca StefflManuela BromDamir KrunicClaudia SchmidtGabriele SchmidtFelix BestvaterJulian TarandaŞevin Turcan

Published in: Neuro-oncology (2022)

Taken together, our results demonstrate that upregulated TRIM67 induces blebbing-based rounded cell morphology through Rho GTPase/ROCK-mediated signaling thereby contributing to glioma pathogenesis.

Keyphrases

protein kinase
single cell
smooth muscle
cell therapy
stem cells
mesenchymal stem cells
bone marrow