Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts.
Jannie Marie Bülow SandHenrik JessenDiana Julie LeemingSheeline YuChris J LeeBuqu HuYing SunTaylor AdamsTaylor PivarnikAngela LiuSamuel WooJohn R McGovernVitória FioriniTina SaberJean Paul Higuero-SevillaMridu GulatiNaftali KaminskiWilliam DamskyAlbert C ShawSubhasis MohantyGillian GoobieYingze ZhangErica Lyndrup HerzogChangwan RyuPublished in: Thorax (2024)
In two well-characterised sarcoidosis cohorts, we discovered that the plasma is enriched for neoepitopes of collagen degradation (C3M and C6M). In multiorgan disease, there was an association with circulating neoepitopes of type III formation (PRO-C3), perhaps mediated by dermatological sarcoidosis. Further investigation in this arena has the potential to foster new insights into the pathogenic mechanisms of this complex disease.