Prognostic value of early changes in CT-measured body composition in patients receiving chemotherapy for unresectable pancreatic cancer.
Emmanuel Salinas-MirandaDominik DeniffelXin DongGerard M HealyFarzad KhalvatiGrainne M O'KaneJennifer KnoxOliver F BatheVickie E BaracosSteven GallingerMasoom A HaiderPublished in: European radiology (2021)
• In patients with unresectable pancreatic ductal adenocarcinoma, change of skeletal muscle index (ΔSMI) in the early phase of chemotherapy is prognostic for overall survival, even after adjusting for Response Evaluation Criteria in Solid Tumors version 1.1 (RECISTv1.1) assessment at first follow-up. • Changes in adipose tissue compartments at first follow-up demonstrated no significant association with overall survival. • Integrating ΔSMI into routine radiological assessment may improve prognostic stratification and impact treatment decision-making at the first follow-up.
Keyphrases
- body composition
- locally advanced
- skeletal muscle
- adipose tissue
- decision making
- rectal cancer
- resistance training
- insulin resistance
- bone mineral density
- squamous cell carcinoma
- radiation therapy
- liver metastases
- computed tomography
- high fat diet
- clinical practice
- magnetic resonance
- contrast enhanced
- image quality
- metabolic syndrome