Anti-spike T-cell and Antibody Responses to SARS-CoV-2 mRNA Vaccines in Patients with Hematologic Malignancies.

Lee M Greenberger Larry A Saltzman Lore M Gruenbaum Jun Xu Sneha T Reddy Jonathon W Senefeld Patrick W Johnson Paul A Fields Catherine Sanders Louis J DeGennaro Gwen L Nichols

Published in: Blood cancer discovery (2022)

This study represents the first investigation of SARS-CoV-2-specific immune responses to vaccination in a patient registry using an NGS-based method for T-cell receptor repertoire-based analysis combined with anti-spike antibody assessments. Vaccinated patients with B cell-derived hematologic malignancies are likely at higher risk of infection or severe COVID-19. This article is highlighted in the In This Issue feature, p. 476.

Keyphrases

sars cov
respiratory syndrome coronavirus
immune response
machine learning
case report
coronavirus disease
dendritic cells
toll like receptor
high throughput sequencing
data analysis