In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes.
Jack LamJonathan M DuBoisJared RowleyOlivier G RoussetKarina A González-OtárulaJean-Paul SoucyGassan MassarwehJeffery A HallMarie-Christine GuiotMaria ZimmermannLuciano MinuzziPedro Rosa-NetoEliane KobayashiPublished in: Epilepsia (2021)
Reduced mGluR5 allosteric site availability in hippocampal CA1-3, measured in vivo by [11 C]ABP688-PET, is associated with postsurgery seizure freedom independent of atrophy or hypometabolism. Information derived from hippocampal CA1-3 [11 C]ABP688-PET is a promising imaging biomarker potentially impactful in surgical decisions for MRI-negative/PET-negative MTLE patients.
Keyphrases
- temporal lobe epilepsy
- pet ct
- positron emission tomography
- computed tomography
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- minimally invasive
- pet imaging
- high resolution
- cerebral ischemia
- type diabetes
- health information
- patient reported outcomes
- magnetic resonance
- coronary artery disease
- adipose tissue
- atrial fibrillation
- skeletal muscle
- protein kinase