Sex-dependent responses to high concentration of binge ethanol in spleen of adolescent F344 rats.

Xiangqian LiuWenfei HuangMuhammed BishirColin HodgkinsonDavid GoldmanSulie L Chang

Published in: Alcohol, clinical & experimental research (2024)

We found that male adolescent rats were more sensitive to binge ethanol than female rats. Differential expression of the genes related to alcohol metabolism and epigenetic modification (of DNA methyltransferase and histone deacetylases) between the sexes could account for the observed sex-dependent responses to binge ethanol in adolescent rats.

Keyphrases

young adults
mental health
dna methylation
gene expression
genome wide
single molecule
cell free
alcohol consumption
nucleic acid