Differential hyperpolarization to substance P and calcitonin gene-related peptide in smooth muscle versus endothelium of mouse mesenteric artery.

Charles E Norton Erika M Boerman Steven S Segal

Published in: Microcirculation (New York, N.Y. : 1994) (2021)

Calcitonin gene-related peptide elicits greater hyperpolarization than substance P. Substance P hyperpolarizes both cell layers through KCa channels and involves endothelium-derived NO in smooth muscle. Endothelial hyperpolarization to CGRP requires KCa channels, while KATP channels mediate hyperpolarization in smooth muscle. Differential K+ channel activation in smooth muscle and endothelium through sensory neurotransmission may selectively tune mesenteric blood flow.

Keyphrases

smooth muscle
blood flow
nitric oxide
copy number
genome wide
single cell
genome wide identification
stem cells
mesenchymal stem cells
bone marrow
transcription factor
drug induced