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Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing.

Ognian NeytchevHelen ErlandssonAnna WitaspLouise NordforsAbdul Rashid QureshiKen IseriHokuto MorohoshiColin SelmanThomas EbertKarolina KublickieneStenvinkel PeterPaul G Shiels
Published in: Journal of internal medicine (2023)
Kidney failure patients displayed an increased biological age as estimated by DNAm clocks compared to population-based controls. Our results suggest that KT, but not dialysis, partially reduces the age acceleration.
Keyphrases
  • end stage renal disease
  • chronic kidney disease
  • kidney transplantation
  • peritoneal dialysis
  • dna methylation
  • prognostic factors