Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model.

Si ShiHua-Jing YinJiang LiLing WangWei-Ping WangXiao-Liang Wang

Published in: CNS neuroscience & therapeutics (2019)

KK-Ay mouse is a useful animal model for studying DE. The alterations of morphology, structure, and function of astrocyte and microglia in KK-Ay mice might be rescued by DR and by treatment of medicine. The proteins we reported in this study could be used as biomarkers and the potential drug targets for DE study and treatment.

Keyphrases

mouse model
type diabetes
inflammatory response
emergency department
early onset
combination therapy
skeletal muscle
smoking cessation
editorial comment