Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension.

Kazufumi NakamuraMasakiyo SakaguchiHiromi MatsubaraSatoshi AkagiToshihiro SarashinaKentaro EjiriKaoru AkazawaMegumi KondoKoji NakagawaMasashi YoshidaToru MiyoshiTakeshi OgoTakahiro OtoShinichi ToyookaYuichiro HigashimotoKei FukamiHiroshi Ito

Published in: PloS one (2018)

RAGE plays a crucial role in the inappropriate increase of PAH-PASMCs. Inhibition of RAGE signaling may be a new therapeutic strategy for PAH.

Keyphrases

pulmonary arterial hypertension
smooth muscle
pulmonary artery
pulmonary hypertension
polycyclic aromatic hydrocarbons