Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives.
Joseph N CapilatoPeter J PellegrinelliJosephine BernardLogan SchnorbusShane PhilippiJoseph MattiucciErik P HoyLark J PerezPublished in: Organic & biomolecular chemistry (2021)
The development of a novel acetyl nitrate mediated oxidative conversion of methyl ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by experimental and computational investigation we propose a mechanism for this transformation.