DNA-polymer conjugates via the graft-through polymerisation of native DNA in water.
Lucy A ArkinstallJonathan T HusbandThomas R WilksJeffrey C FosterRachel K O'ReillyPublished in: Chemical communications (Cambridge, England) (2021)
The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.