Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes.
Gregory L BeutnerRonald CarrasquilloPeng GengYi HsiaoEric C HuangJacob JaneyKishta KatipallySergei KolotuchinThomas La PorteAndrew LeePaul LobbenFederico Lora-GonzalezBrendan MackBoguslaw MudrykYuping QiuXinhua QianAntonio RamirezThomas M RazlerThorsten RosnerZhongping ShiEric M SimmonsJason StevensJianji WangCarolyn WeiSteven R WisniewskiYe ZhuPublished in: Organic letters (2018)
A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.
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