ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients.

Alicja E GrzegorzewskaLeszek NiepolskiMonika K ŚwiderskaAdrianna MostowskaIreneusz StolarekWojciech WarchołMarek FiglerowiczPaweł P Jagodziński

Published in: BMC medical genetics (2018)

Atherogenic dyslipidaemia occurs in HD patients in whom ENHO encodes less adropin. ENHO, RXRA, and LXRA SNPs, separately or jointly, are associated with dyslipidaemia, myocardial infarction, and survival in HD patients. Differences in the availability of transcription binding sites may contribute to these associations.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
peritoneal dialysis
heart failure
gene expression
transcription factor
genome wide
left ventricular
patient reported