The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders.
Sankar Simla PraveenrajSharma SonaliNikhilesh AnandHediyal Ahmed TousifChandrasekaran VichitraManjunath KalyanPerumalswamy Velumani KannaKumar A ChandanaPaneyala ShastharaArehally M MahalakshmiJian YangSeithikurippu R Pandi-PerumalMeena Kishore SakharkarSaravana Babu ChidambaramPublished in: Molecular neurobiology (2022)
Trimethylamine lyases are expressed in a wide range of intestinal microbiota which metabolize dietary nutrients like choline, betaine, and L-carnitine to form trimethylamine (TMA). Trimethylamine N-oxide (TMAO) is an oxidative product of trimethylamine (TMA) catalyzed by the action of flavin monooxygenases (FMO) in the liver. Higher levels of TMAO in the plasma and cerebrospinal fluid (CSF) have been shown to contribute to the development of risk factors and actively promote the pathogenesis of metabolic, cardiovascular, and cerebrovascular diseases. The investigations on the harmful effects of TMAO in the development and progression of neurodegenerative and sleep disorders are summarized in this manuscript. Clinical investigations on the role of TMAO in predicting risk factors and prognostic factors in patients with neurological disorders are also summarized. It is observed that the mechanisms underlying TMAO-mediated pathogenesis include activation of inflammatory signaling pathways such as nuclear factor kappa B (NF-κβ), NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, and MAPK/JNK in the periphery and brain. Data suggests that TMAO levels increase with age-related cognitive dysfunction and also induce mitochondrial dysfunction, oxidative stress, neuronal senescence, and synaptic damage in the brain. Further research into the relationships between dietary food consumption and gut microbiota-dependent TMAO levels could provide novel therapeutic options for neurological illnesses.
Keyphrases
- nuclear factor
- oxidative stress
- signaling pathway
- risk factors
- prognostic factors
- nlrp inflammasome
- toll like receptor
- cerebral ischemia
- cerebrospinal fluid
- pi k akt
- dna damage
- induced apoptosis
- white matter
- resting state
- endothelial cells
- ischemia reperfusion injury
- inflammatory response
- brain injury
- cell proliferation
- cell death
- room temperature
- functional connectivity
- lps induced
- climate change
- binding protein
- data analysis
- subarachnoid hemorrhage
- heavy metals
- endoplasmic reticulum stress
- small molecule