Unveiling the effect of the crystalline phases of iron oxyhydroxide for highly sensitive and selective detection of dopamine.
Sreejesh MoolayadukkamSavithri VishwanathanByeongsun JunSang Uck LeeH S S Ramakrishna MattePublished in: Dalton transactions (Cambridge, England : 2003) (2021)
Electrocatalysis is key to the development of several important energy and biosensing applications. In this regard, the crystalline phase-dependent electrocatalytic activity of materials has been extensively studied for reactions such as hydrogen evolution, oxygen reduction, etc. But such comprehensive studies for evaluating the phase-dependence of electrochemical biosensing have not been undertaken. Herein, three crystalline phases (α-, β-, and γ-) of iron oxyhydroxide (FeOOH) have been synthesized and characterized by spectroscopic and microscopy techniques. Electrochemical studies revealed their high sensitivity and selectivity towards dopamine (DA) detection. Amongst the three electrocatalysts, β-FeOOH shows the highest sensitivity (337.15 μA mM-1 cm-2) and the lowest detection limit (0.56 μM). The enhanced electrocatalytic activity of β-FeOOH, as compared to that of α- and γ-FeOOH, was attributed to its higher active site percentage and facile electrode kinetics. Furthermore, theoretical studies probed into the DA-FeOOH interactions by evaluating the charge transfer characteristics and hydrogen adsorption energies of the three phases to support the experimental findings.
Keyphrases
- label free
- case control
- reduced graphene oxide
- room temperature
- gold nanoparticles
- loop mediated isothermal amplification
- real time pcr
- uric acid
- molecular docking
- metal organic framework
- quantum dots
- density functional theory
- single cell
- single molecule
- high speed
- iron deficiency
- high resolution
- aqueous solution
- highly efficient
- liquid chromatography