Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy.
Nicholas P GreeneSeongkyun LimWesley A HaynieJacob L BrownJohn William DeaverFrancielly Morena Da SilvaLisa T JansenDavid E LeeMichael P WiggsTyrone A WashingtonNicholas P GreenePublished in: Journal of cachexia, sarcopenia and muscle (2021)
These results suggest that the aetiology of disuse muscle atrophy is more complicated and nuanced than previously thought, with different responses based on muscle phenotypes and between males and females, with females having greater inductions of atrophic markers early in the development of disuse atrophy.