Insights on Epidemiology, Pathogenesis, Diagnosis and Possible Treatment of COVID-19 Infection.
Shashank Kumar MauryaAmit BhattacharyaPooja ShuklaRajnikant MishraPublished in: Proceedings of the National Academy of Sciences, India. Section B (2022)
The sudden outbreak of the novel coronavirus infection (COVID-19, SARS-CoV-2 virus) is posing a significant threat by affecting millions of people across the globe showing mild to severe symptoms of pneumonia and acute respiratory distress. The absence of precise information on primary transmission, diagnosis, prognosis, and therapeutics for patients with COVID-19 makes prevention and control tough. In the current scenario, only supportive treatment is available, which in turn possess a biggest challenge for scientists to develop specific drugs and vaccines for COVID-19. Further, India, with the second largest populated country and fluctuating climatic conditions quarterly, has high vulnerability towards COVID-19 infection. Thus, this highlights the importance of a better understanding of the COVID-19 infection, pathology, diagnosis and its treatment. The present review article has been intended to discuss the COVID-19 biology, mechanism of infection in humans with primary effects on pregnancy, the nervous system, diabetes, and cardiovascular disease. The article will also discuss the drug repurposing strategy as an alternative line of treatment and clinical practices recommended by the World Health Organization and other government agencies and represent the COVID-19 scenario with the Indian context.
Keyphrases
- sars cov
- coronavirus disease
- cardiovascular disease
- type diabetes
- healthcare
- primary care
- risk factors
- cardiovascular risk factors
- metabolic syndrome
- skeletal muscle
- early onset
- intensive care unit
- depressive symptoms
- glycemic control
- health information
- hepatitis b virus
- extracorporeal membrane oxygenation
- liver failure
- quantum dots
- aortic dissection
- single molecule