A disposable sensor based on one-pot synthesized tungsten oxide nanostructure-modified screen printed electrodes for selective detection of dopamine and uric acid.
Merve OğuzAhmet AykaçMustafa ŞenPublished in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2023)
Here, screen-printed carbon electrodes (SPCEs) were modified with ultrafine and mainly mono-disperse sea urchin-like tungsten oxide (SUWO 3 ) nanostructures synthesized by a simple one-pot hydrothermal method for non-enzymatic detection of dopamine (DA) and uric acid (UA) in synthetic urine. Sea urchin-like nanostructures were clearly observed in scanning electron microscope images and WO 3 composition was confirmed with XRD, Raman, FTIR and UV-Vis spectrophotometer. Modification of SPCEs with SUWO 3 nanostructures via the drop-casting method clearly reduced the R ct value of the electrodes, lowered the ∆Ep and enhanced the DA oxidation current due to high electrocatalytic activity. As a result, SUWO 3 /SPCEs enabled highly sensitive non-enzymatic detection of DA (LOD: 51.4 nM and sensitivity: 127 µA mM -1 cm -2 ) and UA (LOD: 253 nM and sensitivity: 55.9 µA mM -1 cm -2 ) at low concentration. Lastly, SUWO 3 /SPCEs were tested with synthetic urine, in which acceptable recoveries for both molecules (94.02-105.8%) were obtained. Given the high selectivity, the sensor has the potential to be used for highly sensitive simultaneous detection of DA and UA in real biological samples.
Keyphrases
- uric acid
- label free
- metabolic syndrome
- loop mediated isothermal amplification
- real time pcr
- hydrogen peroxide
- reduced graphene oxide
- high throughput
- photodynamic therapy
- magnetic resonance imaging
- computed tomography
- machine learning
- deep learning
- gold nanoparticles
- magnetic resonance
- fluorescent probe
- mass spectrometry
- particulate matter
- heavy metals
- air pollution
- single molecule
- optical coherence tomography
- sensitive detection
- municipal solid waste