Hepatitis B virus X gene mutants emerge during antiviral therapy and increase cccDNA levels to compensate for replication suppression.

Chih-Lang LinRong-Nan ChienYu-De ChuKung-Hao LiangYa-Hui HuangPo-Yuan KeKwang-Huei LinYang-Hsiang LinChau-Ting Yeh

Published in: Hepatology international (2020)

Our study demonstrates that HBx mutants can emerge during Lamivudine or Entecavir therapy. These mutants exhibit altered transactivation of the HBV pre-S1 and X promoters, leading to increased cccDNA levels to compensate for replication suppression.

Keyphrases

hepatitis b virus
liver failure
wild type
stem cells
genome wide
gene expression
bone marrow
copy number
smoking cessation