Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.

Renyuxue Ma Fengtao You Shuaiyu Tian Tingting Zhang Xiaopeng Tian Shufen Xiang Hai Wu Nan Yang Gangli An Lin Yang

Published in: European journal of haematology (2023)

This study has generated a novel bispecific CAR-T cell that can simultaneously target CD19 or CD22 positive tumor cells, providing a new strategy to address the limitations of single-targeted CAR-T therapy in B-cell tumors (limited response or relapse).

Keyphrases

nk cells
cancer therapy
stem cells
mesenchymal stem cells
drug delivery
cell therapy