Breast cancer stromal clotting activation (Tissue Factor and thrombin): A pre-invasive phenomena that is prognostic in invasion.
Hudhaifah ShakerNigel J BundredGöran LandbergSusan A PritchardHarith AlbadrySarah L NicholsonLauren J HarriesJing Y E HeahJohn CastleCliona Clare KirwanPublished in: Cancer medicine (2020)
This demonstrates procoagulant phenotypic changes occur in fibroblasts at the preinvasive stage. Fibroblast procoagulant phenotype is associated with aggressive breast cancer subtypes and reduced survival. Coagulation may be a therapeutic target in breast cancer.