Two newly-emerging substituted phenethylamines MAL and BOD induce differential psychopharmacological effects in rodents.

Raly James Perez CustodioLeandro Val SaysonChrislean Jun BotanasArvie AbieroMikyung KimHyun Jun LeeHye Won RyuYong Sup LeeHee Jin KimJae Hoon Cheong

Published in: Journal of psychopharmacology (Oxford, England) (2020)

MAL may induce abuse potential via the mesolimbic dopaminergic system and possibly accompanied by alterations in brain wave activity. Moreover, the lack of rewarding and reinforcing effects in BOD suggest that this drug may have little to no capability to engender compulsive behavior, though having found to induce alterations in dopaminergic system and brain wave activities.

Keyphrases

resting state
white matter
multiple sclerosis
functional connectivity
obsessive compulsive disorder
blood brain barrier
cerebral ischemia
molecular dynamics simulations
electronic health record