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Immune landscape and the key role of APOE+ monocytes of lupus nephritis under the single-cell and spatial transcriptional vista.

Youzhou TangYing ZhangXinyu LiRuoyao XuYing JiJishi LiuJianye LiuQuan ZhuangHao Zhang
Published in: Clinical and translational medicine (2023)
In LN, APOE+ Mono are compensatorily elevated, with decreased antigen presenting ability and reduced secretion of interferons. The lymphangiogenesis in LN prompts the trafficking of Mono/MΦ in LN kidney.
Keyphrases
  • single cell
  • cognitive decline
  • high fat diet
  • rna seq
  • gene expression
  • high throughput
  • transcription factor
  • mild cognitive impairment
  • case report
  • type diabetes
  • peripheral blood
  • immune response
  • oxidative stress