The sun, cholesterol and Orai1 conspire in melanoma.

Published in: The EMBO journal (2022)

How does skin cancer become metastatic? A recent study by Gross et al (2022) reports a novel pathway by which UV radiation acts on cholesterol biosynthesis to control Ca 2+ influx by Orai1, causing protein O-GlcNAcylation that promotes transformation to invasive melanoma.

Keyphrases

skin cancer
low density lipoprotein
squamous cell carcinoma
small cell lung cancer
protein protein
radiation induced
children with cerebral palsy