Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors.
Ana Carmena MoratallaYves Carpentier SolorioFlorent LemaitreNegar Farzam-KiaAnnie LevertStephanie E J ZandeeBoaz LahavJean Victor GuimondElie HaddadMarc GirardPierre DuquetteCatherine LarochelleAlexandre PratNathalie ArbourPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
Our study provides new evidence for the involvement of NKG2D and its ligand ULBP4 in MS pathology. Our results point to ULBP4 as a viable target to specifically block 1 component of the NKG2D pathway without altering immune surveillance involving other NKG2DL.