Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration.
Aundrea K WestfallBlair W PerryAbu H M KamalNicole R HalesJarren C KayMadhab SapkotaDrew R SchieldMark W PellegrinoStephen M SecorSaiful M ChowdhuryTodd A CastoePublished in: BMC genomics (2022)
Collectively, our results identify a novel switch-like role of stress responses in intestinal regeneration that forms a primary regulatory hub facilitating organ regeneration and could point to potential pathways to understand regenerative capacity in vertebrates.