Bladder cancer-derived interleukin-1 converts the vascular endothelium into a pro-inflammatory and pro-coagulatory surface.

A JohnC GünesC BolenzS Vidal-Y-SyA T BauerS W SchneiderChristian Gorzelanny

Published in: BMC cancer (2020)

Our data indicate that IL-1 and IL-1ra were dysregulated in bladder cancer and could facilitate tumour dissemination through endothelial cell activation. Targeting the IL-1/IL-1ra axis might attenuate tumour-mediated inflammation and metastasis formation.

Keyphrases

rheumatoid arthritis
nitric oxide
disease activity
big data
electronic health record
machine learning
deep learning