Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8 mnd mice.
Andrew D HolmesKatherine A WhiteMelissa A PrattTyler B JohnsonShibi LikhiteKathrin MeyerJill M WeimerPublished in: Orphanet journal of rare diseases (2022)
Taken together, our results provide further evidence of biologic sex as a modifier of Batten disease progression and outcome, thus warranting consideration when conducting investigations and monitoring therapeutic impact.