Long-term neurocognitive function after whole-brain radiotherapy in patients with melanoma brain metastases in the era of immunotherapy.
Martin SalzmannKlaus HessKristin LangAlexander H EnkBerit JordanJessica C HasselPublished in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2022)
Five of 8 long-term survivors with MBM after WBRT experienced little to no restriction in everyday activities. In 3 out of 8 patients, cognitive decline was primarily explained by localization of the metastases in functionally relevant areas of the brain. The results of our small patient cohort do not support general avoidance of WBRT for treatment of brain metastases. However, long-term studies including pretreatment NCF tests are needed to fully analyze the long-term neurocognitive effects of WBRT.
Keyphrases
- brain metastases
- small cell lung cancer
- cognitive decline
- end stage renal disease
- early stage
- mild cognitive impairment
- bipolar disorder
- white matter
- newly diagnosed
- radiation therapy
- squamous cell carcinoma
- young adults
- prognostic factors
- peritoneal dialysis
- radiation induced
- blood brain barrier
- locally advanced
- case control